Ivermectin Injection for Cattle and Swine for Animal Use
Sep. 11, 2021
Ivermectin is an injectable wormicide for use in cattle and pigs. A low dose dosage is effective in the treatment and control of the following internal and external parasites that can be detrimental to the health of cattle and pigs: gastrointestinal roundworms (including inhibitory Ostertagia ostertagi in cattle), lung nematodes, grubs, sucking lice and mange mites in cattle; and gastrointestinal roundworms, lungworms, lice and mange mites in pigs.
Ivermectin is derived from avermectin, a family of potent broad-spectrum anti-parasitic agents isolated from the fermentation of Streptomyces avermitilis.
Ivermectin Injection is a clear, ready-to-use, sterile solution containing 1% ivermectin, 40% glycerol formaldehyde and propylene glycol, qs ad 100%. Ivermectin Injection is formulated to deliver the recommended dose level of 200 mcg ivermectin/kg body weight in cattle when administered subcutaneously at a rate of 1 mL/110 lb (50 kg). In pigs, Ivermectin Injection is formulated to deliver the recommended dose level of 300 mcg ivermectin/kg bw when administered subcutaneously at a rate of 1 mL/75 lb (33 kg) in the neck.
Mode of action
Ivermectin is a member of the macrolide class of insecticides with a unique mode of action. This class of compounds selectively binds to and has high affinity for glutamate-gated chloride channels, which are found in invertebrate nerve and muscle cells. This results in increased permeability of the cell membrane to chloride ions and hyperpolarisation of nerve or muscle cells, leading to paralysis and death of the parasite. These compounds can also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The safe range of such compounds is attributed to the absence of glutamate-gated chloride channels in mammals, the low affinity of macrolides for other mammalian ligand-gated chloride channels, and the fact that they do not readily cross blood-brain barriers.
Bovine: Ivermectin should be administered only by subcutaneous injection under the loose skin in front or behind the shoulder at the recommended dose level of 200 µg ivermectin per kg body weight. Each ml of ivermectin contains 10 mg of ivermectin and is sufficient to treat 110 lbs (50 kg) of body weight (maximum 10 ml per injection site).
Pigs: Ivermectin should only be administered by subcutaneous injection into the neck of pigs at the recommended dose level of 300 µg ivermectin per kg (2.2 lbs) of body weight. Each ml of ivermectin contains 10 mg of ivermectin, which is sufficient to treat a body weight of 75 lbs.
Cattle: Ivermectin Injection should only be administered subcutaneously to reduce the risk of potentially fatal Clostridium difficile infection at the injection site.
Animals should be properly restrained to achieve the correct route of administration. A 16 gauge 1/2 to 3/4" needle is recommended. Inject under loose skin in front or behind the shoulder (see diagram). When using the 200 mL, 500 mL sizes, use only auto-injector equipment. Use sterile equipment and disinfect the injection site with a suitable disinfectant. Clean, properly sterilised needles should be used to reduce the possibility of infection at the injection site. No special handling or protective clothing is required.
Pigs: Ivermectin injection is given subcutaneously in the neck. The animal should be properly restrained to achieve the correct route of administration. A 16 or 18 gauge needle is recommended for sows and gilts, while an 18 or 20 gauge needle may be suitable for young animals. Inject subcutaneously, immediately behind the ear (see diagram). When using the 200 mL, 500 mL sizes, use only auto-injector equipment. As with any injection, sterile equipment should be used. The injection site should be cleaned and disinfected with alcohol prior to injection. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. After subcutaneous administration, some pigs may experience a mild and transient painful reaction.