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What Do You Know about Oxytetracycline?

Dec. 07, 2020

Oxytetracycline belongs to the tetracycline group and has an inhibitory effect on many gram-positive and gram-negative bacteria, such as Bordetella, Campylobacter, Chlamydia, E. coli, Haemophilus, Mycoplasma, Pasteurella, Rickettsia, Salmonella, Staphylococcus, and Streptococcus. The action of oxytetracycline is based on the inhibition of bacterial protein synthesis. Oxytetracycline is mainly excreted in the urine, with a small portion excreted in bile and in lactating animals. A single injection lasts two days. Oxytetracycline supplier will explain the indications for oxytetracycline injection and the pharmacological effects of oxytetracycline injection.

Indications for Oxytetracycline Injection

It can be used for the treatment of calf dysentery, lamb dysentery, piglet dysentery and dysentery, chick dysentery caused by E. coli or Salmonella; bovine hemorrhagic septicemia, swine pneumonia and avian cholera caused by Pasteurella multocida; bovine pneumonia, swine asthma and chronic respiratory disease of chickens caused by Mycoplasma spp. It is also effective against Thalassaemia, actinomycosis and leptospirosis caused by Haematobium infection. It can also be used topically for necrosis caused by Necrobacterium necrophorum, uterine abscess and endometritis.

Oxytetracycline Injection

Oxytetracycline injection pharmacological action

This product is yellow to light brownish yellow clear liquid; or amber clear liquid, with a special odor; or yellow to reddish brown viscous liquid.

It is a broad-spectrum antibiotic with a strong effect on Gram-positive bacteria such as Staphylococcus, Streptococcus hemolyticus, Bacillus anthracis, Clostridium tetani, and Clostridium clostridium, but not as strong as β-lactams. It is more sensitive to Gram-negative bacteria such as Escherichia coli, Salmonella, Brucella and Pasteurella, but not as strong as aminoglycosides and aminoglycosides. It also inhibits rickettsia, chlamydia, mycoplasma, spirochetes, actinomycetes, and certain protozoa.

The internal absorption of oxytetracycline is unplanned and incomplete, and it is easily absorbed in starved animals, with a bioavailability of about 60%-80%, mainly in the upper part of the small intestine. The magnesium, aluminum, iron, zinc, manganese and other valence-capturing metal ions in the gastrointestinal tract can form insoluble stinging compounds with the product and reduce the absorption of the drug, and the stomach contents can reduce the absorption by 50% or more. After internal administration, the blood concentration peaks in 2-4 hours. The peak time after intramuscular injection ranges from 30 minutes to several hours, depending on the injection site and volume. After absorption, it is widely distributed in the body and readily penetrates into the thoracic, abdominal cavity, and breast milk, and also crosses the placental barrier into the fetal circulation, but its concentration in the cerebrospinal fluid is low. Oxytetracycline is mainly excreted in its original form by glomerular filtration, but in renal dysfunction, excretion is slowed and the half-life is prolonged. The half-life of oxytetracycline is 10.5 hours for horses, 4.3-9.7 hours for cattle, 6.7 hours for pigs, and 4-6 hours for dogs and cats.